ctrl v leri alalım gececi tayfa

CYP3A7 is the dominant CYP3A isoform found in fetal liver [9,108].
Gene transcription and protein expression appears to be reduced after
birth [9] and mRNA is often very low or undetectable in Caucasian
adults [31]. Because the CYP3A7*1C variant has an altered promoter
sequence compared to the wild-type allele, it was suggested that
these base changes, particularly those found in the ER-6 motif,
would result in increased protein expression in the adult liver [17].
Indeed, an analysis of CYP3A7 mRNA from five livers with a
CYP3A7*1C genotype and four livers homozygous for the wild-type
allele, revealed that the two livers with the highest level of CYP3A7
mRNA carried the CYP3A7*1C allele [17]. Moreover, four of five livers
with a CYP3A7*1C allele had detectable message, whereas those
homozygous for CYP3A7*1A had either undetectable or low CYP3A7
mRNA. It was concluded that the CYP3A7*1C variant was associated
with significant CYP3A7 expression in adult liver, but that this variant
may not be the sole determinant of expression